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Reintroducing testosterone in the db/db mouse partially restores normal glucose metabolism and insulin resistance in a leptin-independent manner

BACKGROUND: Testosterone signals through the androgen receptor (AR) and AR knockout mice develop obesity, suggesting a functional association between AR and leptin signaling. Furthermore, physiological blood concentrations of testosterone have been found to inhibit the development of arteriosclerosi...

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Detalles Bibliográficos
Autores principales: Yabiku, Koichi, Nakamoto, Keiko, Tokushige, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998571/
https://www.ncbi.nlm.nih.gov/pubmed/29895265
http://dx.doi.org/10.1186/s12902-018-0266-y