Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients

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Retinitis pigmentosa (RP) is an irreversible, inherited retinopathy in which early-onset nyctalopia is observed. Despite the genetic heterogeneity of RP, RPGR mutations are the most common causes of this disease. Here, we generated induced pluripotent stem cells (iPSCs) from three RP patients with d...

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Detalles Bibliográficos
Autores principales: Deng, Wen-Li, Gao, Mei-Ling, Lei, Xin-Lan, Lv, Ji-Neng, Zhao, Huan, He, Kai-Wen, Xia, Xi-Xi, Li, Ling-Yun, Chen, Yu-Chen, Li, Yan-Ping, Pan, Deng, Xue, Tian, Jin, Zi-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998840/
https://www.ncbi.nlm.nih.gov/pubmed/29526738
http://dx.doi.org/10.1016/j.stemcr.2018.02.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998840/
https://www.ncbi.nlm.nih.gov/pubmed/29526738
http://dx.doi.org/10.1016/j.stemcr.2018.02.003

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