Non-equilibrium repressor binding kinetics link DNA damage dose to transcriptional timing within the SOS gene network

Biochemical pathways are often genetically encoded as simple transcription regulation networks, where one transcription factor regulates the expression of multiple genes in a pathway. The relative timing of each promoter’s activation and shut-off within the network can impact physiology. In the DNA...

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Detalles Bibliográficos
Autores principales: Culyba, Matthew J., Kubiak, Jeffrey M., Mo, Charlie Y., Goulian, Mark, Kohli, Rahul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999292/
https://www.ncbi.nlm.nih.gov/pubmed/29856734
http://dx.doi.org/10.1371/journal.pgen.1007405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999292/
https://www.ncbi.nlm.nih.gov/pubmed/29856734
http://dx.doi.org/10.1371/journal.pgen.1007405

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