First-in-human randomized clinical trials of the safety and efficacy of tanezumab for treatment of chronic knee osteoarthritis pain or acute bunionectomy pain

INTRODUCTION: The neurotrophin nerve growth factor has a demonstrated role in pain transduction and pathophysiology. OBJECTIVES: Two randomized, double-blind, placebo-controlled, phase 1 studies were conducted to evaluate safety, tolerability, and analgesic efficacy of single doses of tanezumab, a h...

Descripción completa

Detalles Bibliográficos
Autores principales: Walicke, Patricia A., Hefti, Franz, Bales, Roxanne, Lu, Shiao-Ping, Ruckle, Jon L., Brown, Mark T., West, Christine R., Shelton, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2018
Materias:
Musculoskeletal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999411/
https://www.ncbi.nlm.nih.gov/pubmed/29922745
http://dx.doi.org/10.1097/PR9.0000000000000653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999411/
https://www.ncbi.nlm.nih.gov/pubmed/29922745
http://dx.doi.org/10.1097/PR9.0000000000000653

Ejemplares similares