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Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma

The Hedgehog (Hh) signalling pathway is involved in cell differentiation, growth and tissue polarity. This pathway is also involved in the progression and invasion of various human cancers. Osteosarcoma, a subtype of bone cancer, is commonly seen in children and adolescents. Typically, pulmonary ost...

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Autores principales: Yao, Zhihong, Han, Lei, Chen, Yongbin, He, Fei, Sun, Bin, kamar, Santosh, Zhang, Ya, Yang, Yihao, Wang, Cao, Yang, Zuozhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999604/
https://www.ncbi.nlm.nih.gov/pubmed/29899399
http://dx.doi.org/10.1038/s41419-018-0647-1
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author Yao, Zhihong
Han, Lei
Chen, Yongbin
He, Fei
Sun, Bin
kamar, Santosh
Zhang, Ya
Yang, Yihao
Wang, Cao
Yang, Zuozhang
author_facet Yao, Zhihong
Han, Lei
Chen, Yongbin
He, Fei
Sun, Bin
kamar, Santosh
Zhang, Ya
Yang, Yihao
Wang, Cao
Yang, Zuozhang
author_sort Yao, Zhihong
collection PubMed
description The Hedgehog (Hh) signalling pathway is involved in cell differentiation, growth and tissue polarity. This pathway is also involved in the progression and invasion of various human cancers. Osteosarcoma, a subtype of bone cancer, is commonly seen in children and adolescents. Typically, pulmonary osteosarcoma metastases are especially difficult to control. In the present paper, we summarise recent studies on the regulation of osteosarcoma progression and metastasis by downregulating Hh signalling. We also summarise the crosstalk between the Hh pathway and other cancer-related pathways in the tumourigenesis of various cancers. We further summarise and highlight the therapeutic value of potential inhibitors of Hh signalling in the clinical therapy of human cancers.
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spelling pubmed-59996042018-06-14 Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma Yao, Zhihong Han, Lei Chen, Yongbin He, Fei Sun, Bin kamar, Santosh Zhang, Ya Yang, Yihao Wang, Cao Yang, Zuozhang Cell Death Dis Review Article The Hedgehog (Hh) signalling pathway is involved in cell differentiation, growth and tissue polarity. This pathway is also involved in the progression and invasion of various human cancers. Osteosarcoma, a subtype of bone cancer, is commonly seen in children and adolescents. Typically, pulmonary osteosarcoma metastases are especially difficult to control. In the present paper, we summarise recent studies on the regulation of osteosarcoma progression and metastasis by downregulating Hh signalling. We also summarise the crosstalk between the Hh pathway and other cancer-related pathways in the tumourigenesis of various cancers. We further summarise and highlight the therapeutic value of potential inhibitors of Hh signalling in the clinical therapy of human cancers. Nature Publishing Group UK 2018-06-13 /pmc/articles/PMC5999604/ /pubmed/29899399 http://dx.doi.org/10.1038/s41419-018-0647-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Yao, Zhihong
Han, Lei
Chen, Yongbin
He, Fei
Sun, Bin
kamar, Santosh
Zhang, Ya
Yang, Yihao
Wang, Cao
Yang, Zuozhang
Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma
title Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma
title_full Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma
title_fullStr Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma
title_full_unstemmed Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma
title_short Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma
title_sort hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999604/
https://www.ncbi.nlm.nih.gov/pubmed/29899399
http://dx.doi.org/10.1038/s41419-018-0647-1
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