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Heparin Oligosaccharides Have Antiarrhythmic Effect by Accelerating the Sodium-Calcium Exchanger

Background: Blockage of the Na(+)/Ca(2+) exchanger (NCX) is used to determine the role of NCX in arrhythmogenesis. Trisulfated heparin disaccharide (TD) and Low Molecular Weight Heparins (LMWHs) can directly interact with the NCX and accelerate its activity. Objective: In this work, we investigated...

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Detalles Bibliográficos
Autores principales: de Godoy, Carlos M. G., Vasques, Ênio R., Caricati-Neto, Afonso, Tavares, José G. P., Alves, Beatriz J., Duarte, Juliana, Miranda-Ferreira, Regiane, Lima, Marcelo A., Nader, Helena B., Tersariol, Ivarne L. dos Santos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999778/
https://www.ncbi.nlm.nih.gov/pubmed/29930947
http://dx.doi.org/10.3389/fcvm.2018.00067