Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson’s disease

α-synuclein abnormal accumulation and mitochondria dysfunction are involved in the pathogenesis of Parkinson’s disease. Selective autophagy of mitochondria (mitophagy) is a crucial component of the network controlling the mitochondrial homeostasis. However, the underlying mechanism that mutant α-syn...

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Detalles Bibliográficos
Autores principales: Chen, Jialong, Ren, Yixian, Gui, Chen, Zhao, Menglan, Wu, Xian, Mao, Kanmin, Li, Wenjun, Zou, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999948/
https://www.ncbi.nlm.nih.gov/pubmed/29899409
http://dx.doi.org/10.1038/s41419-018-0722-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5999948/
https://www.ncbi.nlm.nih.gov/pubmed/29899409
http://dx.doi.org/10.1038/s41419-018-0722-7

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