KLF4 Nuclear Export Requires ERK Activation and Initiates Exit from Naive Pluripotency

Cooperative action of a transcription factor complex containing OCT4, SOX2, NANOG, and KLF4 maintains the naive pluripotent state; however, less is known about the mechanisms that disrupt this complex, initiating exit from pluripotency. We show that, as embryonic stem cells (ESCs) exit pluripotency,...

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Detalles Bibliográficos
Autores principales: Dhaliwal, Navroop K., Miri, Kamelia, Davidson, Scott, Tamim El Jarkass, Hala, Mitchell, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000723/
https://www.ncbi.nlm.nih.gov/pubmed/29526737
http://dx.doi.org/10.1016/j.stemcr.2018.02.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000723/
https://www.ncbi.nlm.nih.gov/pubmed/29526737
http://dx.doi.org/10.1016/j.stemcr.2018.02.007

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