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KLF4 Nuclear Export Requires ERK Activation and Initiates Exit from Naive Pluripotency
Cooperative action of a transcription factor complex containing OCT4, SOX2, NANOG, and KLF4 maintains the naive pluripotent state; however, less is known about the mechanisms that disrupt this complex, initiating exit from pluripotency. We show that, as embryonic stem cells (ESCs) exit pluripotency,...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000723/ https://www.ncbi.nlm.nih.gov/pubmed/29526737 http://dx.doi.org/10.1016/j.stemcr.2018.02.007 |