Knockdown of KLF5 suppresses hypoxia-induced resistance to cisplatin in NSCLC cells by regulating HIF-1α-dependent glycolysis through inactivation of the PI3K/Akt/mTOR pathway

BACKGROUND: Hypoxia-mediated chemoresistance has been regarded as an important obstacle in the development of cancer treatment. Knockdown of krüppel-like factor 5 (KLF5) was reported to inhibit hypoxia-induced cell survival and promote cell apoptosis in non-small cell lung cancer (NSCLC) cells via d...

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Detalles Bibliográficos
Autores principales: Gong, Tianxiao, Cui, Liuqing, Wang, Haili, Wang, Haoxun, Han, Na
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000925/
https://www.ncbi.nlm.nih.gov/pubmed/29898734
http://dx.doi.org/10.1186/s12967-018-1543-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000925/
https://www.ncbi.nlm.nih.gov/pubmed/29898734
http://dx.doi.org/10.1186/s12967-018-1543-2

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