Inhibition of calcium/calmodulin-dependent kinase II restores contraction and relaxation in isolated cardiac muscle from type 2 diabetic rats

BACKGROUND: Calcium/calmodulin-dependent kinase II-delta (CaMKIIδ) activity is enhanced during hyperglycemia and has been shown to alter intracellular calcium handling in cardiomyocytes, ultimately leading to reduced cardiac performance. However, the effects of CaMKIIδ on cardiac contractility durin...

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Detalles Bibliográficos
Autores principales: Daniels, Lorna J., Wallace, Rachel S., Nicholson, Olivia M., Wilson, Genevieve A., McDonald, Fiona J., Jones, Peter P., Baldi, J. Chris, Lamberts, Regis R., Erickson, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001139/
https://www.ncbi.nlm.nih.gov/pubmed/29903013
http://dx.doi.org/10.1186/s12933-018-0732-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001139/
https://www.ncbi.nlm.nih.gov/pubmed/29903013
http://dx.doi.org/10.1186/s12933-018-0732-x

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