Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket

Activating mutations within the epidermal growth factor receptor (EGFR) kinase domain give rise to several cancers including Non-Small Cell Lung Cancer (NSCLC). Small molecule inhibitors targeted at these mutants have proven to be clinically successful drugs. These molecules are ATP competitive and...

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Detalles Bibliográficos
Autores principales: Kannan, Srinivasaraghavan, Venkatachalam, Gireedhar, Lim, Hong Hwa, Surana, Uttam, Verma, Chandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001276/
https://www.ncbi.nlm.nih.gov/pubmed/29997876
http://dx.doi.org/10.1039/c8sc01262h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001276/
https://www.ncbi.nlm.nih.gov/pubmed/29997876
http://dx.doi.org/10.1039/c8sc01262h

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