Copper mediated C–H amination with oximes: en route to primary anilines

Here we report an efficient Cu(i)-mediated C–H amination reaction with oximes as amino donors to introduce NH(2) groups directly. Various strongly coordinating heterocycles including quinoline, pyrimidine, pyrazine, pyrazole and triazole were tolerated well. The potential utility was further demonst...

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Detalles Bibliográficos
Autores principales: Xu, Lin-Lin, Wang, Xing, Ma, Biao, Yin, Ming-Xing, Lin, Hai-Xia, Dai, Hui-Xiong, Yu, Jin-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001278/
https://www.ncbi.nlm.nih.gov/pubmed/29997868
http://dx.doi.org/10.1039/c8sc01256c
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author Xu, Lin-Lin
Wang, Xing
Ma, Biao
Yin, Ming-Xing
Lin, Hai-Xia
Dai, Hui-Xiong
Yu, Jin-Quan
author_facet Xu, Lin-Lin
Wang, Xing
Ma, Biao
Yin, Ming-Xing
Lin, Hai-Xia
Dai, Hui-Xiong
Yu, Jin-Quan
author_sort Xu, Lin-Lin
collection PubMed
description Here we report an efficient Cu(i)-mediated C–H amination reaction with oximes as amino donors to introduce NH(2) groups directly. Various strongly coordinating heterocycles including quinoline, pyrimidine, pyrazine, pyrazole and triazole were tolerated well. The potential utility was further demonstrated in a late-stage modification of telmisartan (an antagonist for the angiotensin II receptor).
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spelling pubmed-60012782018-07-11 Copper mediated C–H amination with oximes: en route to primary anilines Xu, Lin-Lin Wang, Xing Ma, Biao Yin, Ming-Xing Lin, Hai-Xia Dai, Hui-Xiong Yu, Jin-Quan Chem Sci Chemistry Here we report an efficient Cu(i)-mediated C–H amination reaction with oximes as amino donors to introduce NH(2) groups directly. Various strongly coordinating heterocycles including quinoline, pyrimidine, pyrazine, pyrazole and triazole were tolerated well. The potential utility was further demonstrated in a late-stage modification of telmisartan (an antagonist for the angiotensin II receptor). Royal Society of Chemistry 2018-05-14 /pmc/articles/PMC6001278/ /pubmed/29997868 http://dx.doi.org/10.1039/c8sc01256c Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by-nc/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)
spellingShingle Chemistry
Xu, Lin-Lin
Wang, Xing
Ma, Biao
Yin, Ming-Xing
Lin, Hai-Xia
Dai, Hui-Xiong
Yu, Jin-Quan
Copper mediated C–H amination with oximes: en route to primary anilines
title Copper mediated C–H amination with oximes: en route to primary anilines
title_full Copper mediated C–H amination with oximes: en route to primary anilines
title_fullStr Copper mediated C–H amination with oximes: en route to primary anilines
title_full_unstemmed Copper mediated C–H amination with oximes: en route to primary anilines
title_short Copper mediated C–H amination with oximes: en route to primary anilines
title_sort copper mediated c–h amination with oximes: en route to primary anilines
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001278/
https://www.ncbi.nlm.nih.gov/pubmed/29997868
http://dx.doi.org/10.1039/c8sc01256c
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