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Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice

OBJECTIVE: Both Type I and Type II diabetes mellitus result from insufficient functional β-cell mass. Efforts to increase β-cell proliferation as a means to restore β-cell mass have been met with limited success. Suppression of Tumorigenicity 5 (ST5) activates Ras/Erk signaling in the presence of Ep...

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Detalles Bibliográficos
Autores principales: Ou, Kristy, Zhang, Jia, Jiao, Yang, Wang, Zhao V., Scherer, Phillipp, Kaestner, Klaus H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001393/
https://www.ncbi.nlm.nih.gov/pubmed/29650351
http://dx.doi.org/10.1016/j.molmet.2018.03.009