Synthesis and applications of highly functionalized 1-halo-3-substituted bicyclo[1.1.1]pentanes

Bicyclo[1.1.1]pentanes (BCPs) are important bioisosteres of 1,4-disubstituted arenes, tert-butyl and acetylenic groups that can impart physicochemical benefits on drug candidates. Here we describe the synthesis of BCPs bearing carbon and halogen substituents under exceptionally mild reaction conditi...

Descripción completa

Detalles Bibliográficos
Autores principales: Caputo, Dimitri F. J., Arroniz, Carlos, Dürr, Alexander B., Mousseau, James J., Stepan, Antonia F., Mansfield, Steven J., Anderson, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001403/
https://www.ncbi.nlm.nih.gov/pubmed/29997886
http://dx.doi.org/10.1039/c8sc01355a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001403/
https://www.ncbi.nlm.nih.gov/pubmed/29997886
http://dx.doi.org/10.1039/c8sc01355a

Ejemplares similares