Blocking variant surface glycoprotein synthesis alters endoplasmic reticulum exit sites/Golgi homeostasis in Trypanosoma brucei

The predominant secretory cargo of bloodstream form Trypanosoma brucei is variant surface glycoprotein (VSG), comprising ~10% total protein and forming a dense protective layer. Blocking VSG translation using Morpholino oligonucleotides triggered a precise pre‐cytokinesis arrest. We investigated the...

Descripción completa

Detalles Bibliográficos
Autores principales: Ooi, Cher‐Pheng, Smith, Terry K., Gluenz, Eva, Wand, Nadina Vasileva, Vaughan, Sue, Rudenko, Gloria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons A/S 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001540/
https://www.ncbi.nlm.nih.gov/pubmed/29533496
http://dx.doi.org/10.1111/tra.12561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001540/
https://www.ncbi.nlm.nih.gov/pubmed/29533496
http://dx.doi.org/10.1111/tra.12561

Ejemplares similares