Cargando…

Blocking variant surface glycoprotein synthesis alters endoplasmic reticulum exit sites/Golgi homeostasis in Trypanosoma brucei

The predominant secretory cargo of bloodstream form Trypanosoma brucei is variant surface glycoprotein (VSG), comprising ~10% total protein and forming a dense protective layer. Blocking VSG translation using Morpholino oligonucleotides triggered a precise pre‐cytokinesis arrest. We investigated the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ooi, Cher‐Pheng, Smith, Terry K., Gluenz, Eva, Wand, Nadina Vasileva, Vaughan, Sue, Rudenko, Gloria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons A/S 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001540/ https://www.ncbi.nlm.nih.gov/pubmed/29533496 http://dx.doi.org/10.1111/tra.12561

Ejemplares similares

The role of genomic location and flanking 3′UTR in the generation of functional levels of variant surface glycoprotein in Trypanosoma brucei
por: Ridewood, Sophie, et al.
Publicado: (2017)

Blocking Synthesis of the Variant Surface Glycoprotein Coat in Trypanosoma brucei Leads to an Increase in Macrophage Phagocytosis Due to Reduced Clearance of Surface Coat Antibodies
por: Cheung, Jackie L. Y., et al.
Publicado: (2016)

Blocking Variant Surface Glycoprotein Synthesis in Trypanosoma brucei Triggers a General Arrest in Translation Initiation
por: Smith, Terry K., et al.
Publicado: (2009)

More than meets the eye: understanding Trypanosoma brucei morphology in the tsetse
por: Ooi, Cher-Pheng, et al.
Publicado: (2013)

TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei
por: Davies, Carys, et al.
Publicado: (2021)

Trypanosoma brucei: Trypanosome-specific endoplasmic reticulum proteins involved in variant surface glycoprotein expression
por: Wang, Ya-Nan, et al.
Publicado: (2010)

Golgi duplication in Trypanosoma brucei
por: He, Cynthia Y., et al.
Publicado: (2004)

Dynamic Capture and Release of Endoplasmic Reticulum Exit Sites by Golgi Stacks in Arabidopsis
por: Takagi, Junpei, et al.
Publicado: (2020)

The Flagellar Arginine Kinase in Trypanosoma brucei Is Important for Infection in Tsetse Flies
por: Ooi, Cher-Pheng, et al.
Publicado: (2015)

Histone H1 Plays a Role in Heterochromatin Formation and VSG Expression Site Silencing in Trypanosoma brucei
por: Povelones, Megan L., et al.
Publicado: (2012)

Endoplasmic reticulum–associated degradation and disposal of misfolded GPI-anchored proteins in Trypanosoma brucei
por: Tiengwe, Calvin, et al.
Publicado: (2018)

The endoplasmic reticulum membrane protein complex localizes to the mitochondrial - endoplasmic reticulum interface and its subunits modulate phospholipid biosynthesis in Trypanosoma brucei
por: Iyer, Advaitha, et al.
Publicado: (2022)

Retention of glucose units added by the UDP-GLC:glycoprotein glucosyltransferase delays exit of glycoproteins from the endoplasmic reticulum
Publicado: (1995)

Structural asymmetry and discrete nucleic acid subdomains in the Trypanosoma brucei kinetoplast
por: Gluenz, Eva, et al.
Publicado: (2007)

The heart of darkness: growth and form of Trypanosoma brucei in the tsetse fly
por: Sharma, Reuben, et al.
Publicado: (2009)

Endoplasmic reticulum and Golgi stress in microcephaly
por: Passemard, Sandrine, et al.
Publicado: (2019)

The endoplasmic reticulum—Golgi intermediate compartment
por: Hauri, Hans-Peter, et al.
Publicado: (1992)

Do trypanosome turncoats wait before they commit?
por: Ooi, Cher-Pheng, et al.
Publicado: (2014)

How to create coats for all seasons: elucidating antigenic variation in African trypanosomes
por: Ooi, Cher-Pheng, et al.
Publicado: (2017)

Turnover of Variant Surface Glycoprotein in Trypanosoma brucei Is a Bimodal Process
por: Garrison, Paige, et al.
Publicado: (2021)

Polo-like kinase is required for Golgi and bilobe biogenesis in Trypanosoma brucei
por: de Graffenried, Christopher L., et al.
Publicado: (2008)

Basal body structure and cell cycle-dependent biogenesis in Trypanosoma brucei
por: Vaughan, Sue, et al.
Publicado: (2016)

The beads in the Golgi complex-endoplasmic reticulum region
Publicado: (1976)

Membrane Dynamics at the Endoplasmic Reticulum–Golgi Interface
por: Bannykh, Sergei I., et al.
Publicado: (1997)

Antibodies to the Golgi complex and the rough endoplasmic reticulum
Publicado: (1982)

Retention and retrieval in the endoplasmic reticulum and the Golgi apparatus
por: Nilsson, Tommy, et al.
Publicado: (1994)

Intracellular transport of a variant surface glycoprotein in Trypanosoma brucei
Publicado: (1988)

The Spliced Leader RNA Silencing (SLS) Pathway in Trypanosoma brucei Is Induced by Perturbations of Endoplasmic Reticulum, Golgi Complex, or Mitochondrial Protein Factors: Functional Analysis of SLS-Inducing Kinase PK3
por: Okalang, Uthman, et al.
Publicado: (2021)

The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei
por: Young, Simon A, et al.
Publicado: (2010)

The endoplasmic reticulum-associated mRNA-binding proteins ERBP1 and ERBP2 interact in bloodstream-form Trypanosoma brucei
por: Bajak, Kathrin, et al.
Publicado: (2020)

Intracellular colocalization of variant surface glycoprotein and transferrin-gold in Trypanosoma brucei
Publicado: (1988)

Identification of Peptide Mimotopes of Trypanosoma brucei gambiense Variant Surface Glycoproteins
por: Van Nieuwenhove, Liesbeth Carolien, et al.
Publicado: (2011)

Glycotyping of Trypanosoma brucei variant surface glycoprotein MITat1.8
por: Mehlert, Angela, et al.
Publicado: (2010)

Cell type-specific post-Golgi apparatus localization of a "resident" endoplasmic reticulum glycoprotein, glucosidase II
Publicado: (1990)

gp74 a membrane glycoprotein of the cis-Golgi network that cycles through the endoplasmic reticulum and intermediate compartment
Publicado: (1994)

The Endoplasmic Reticulum and the Golgi Structures in Maize Root Cells
por: Whaley, W. Gordon, et al.
Publicado: (1959)

A role for endoplasmic reticulum exit sites in foot-and-mouth disease virus infection
por: Midgley, Rebecca, et al.
Publicado: (2013)

Functional characterization of cohesin subunit SCC1 in Trypanosoma brucei and dissection of mutant phenotypes in two life cycle stages
por: Gluenz, Eva, et al.
Publicado: (2008)

Screening ciliopathy genes in the model organism Trypanosoma brucei
por: Barry, S, et al.
Publicado: (2012)

A membrane glycoprotein, Sec12p, required for protein transport from the endoplasmic reticulum to the Golgi apparatus in yeast
Publicado: (1988)

Cannot write session to /tmp/vufind_sessions/sess_mr4bsjmsid6kjk77amisnm6fnt