Synthesis and molecular modelling studies of pyrimidinones and pyrrolo[3,4-d]-pyrimidinodiones as new antiplasmodial compounds

BACKGROUND: Malaria is responsible for 429,000 deaths per year worldwide, and more than 200 million cases were reported in 2015. Increasing parasite resistance has imposed restrictions to the currently available antimalarial drugs. Thus, the search for new, effective and safe antimalarial drugs is c...

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Detalles Bibliográficos
Autores principales: Rogerio, Kamilla Rodrigues, Carvalho, Leonardo J M, Domingues, Luiza Helena Pinto, Neves, Bruno Junior, Moreira, José Teófilo, Castro, Rosane Nora, Bianco, Cesare, Daniel-Ribeiro, Claudio Tadeu, Andrade, Carolina Horta, Graebin, Cedric Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001580/
https://www.ncbi.nlm.nih.gov/pubmed/29924131
http://dx.doi.org/10.1590/0074-02760170452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001580/
https://www.ncbi.nlm.nih.gov/pubmed/29924131
http://dx.doi.org/10.1590/0074-02760170452

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