Ultrasensitive Capture of Human Herpes Simplex Virus Genomes Directly from Clinical Samples Reveals Extraordinarily Limited Evolution in Cell Culture

Herpes simplex viruses (HSVs) are difficult to sequence due to their large DNA genome, high GC content, and the presence of repeats. To date, most HSV genomes have been recovered from culture isolates, raising concern that these genomes may not accurately represent circulating clinical strains. We r...

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Detalles Bibliográficos
Autores principales: Greninger, Alexander L., Roychoudhury, Pavitra, Xie, Hong, Casto, Amanda, Cent, Anne, Pepper, Gregory, Koelle, David M., Huang, Meei-Li, Wald, Anna, Johnston, Christine, Jerome, Keith R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001610/
https://www.ncbi.nlm.nih.gov/pubmed/29898986
http://dx.doi.org/10.1128/mSphereDirect.00283-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001610/
https://www.ncbi.nlm.nih.gov/pubmed/29898986
http://dx.doi.org/10.1128/mSphereDirect.00283-18

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