Cargando…

FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis

F-box and WD repeat domain-containing 7 (FBW7) functions as a major tumor suppressor by targeting oncoproteins for degradations. FBW7 has been reported to be one of the most frequently mutated genes in colorectal cancer (CRC). However, its roles and possible mechanisms in the development of CRC are...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Qingguo, Li, Yaqi, Li, Jing, Ma, Yanlei, Dai, Weixing, Mo, Shaobo, Xu, Ye, Li, Xinxiang, Cai, Sanjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001674/ https://www.ncbi.nlm.nih.gov/pubmed/29910683 http://dx.doi.org/10.7150/ijbs.24505

Ejemplares similares

Changes in Incidence and Survival by Decade of Patients With Primary Colorectal Lymphoma: A SEER Analysis
por: Li, Qingguo, et al.
Publicado: (2020)

Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis
por: Li, Qingguo, et al.
Publicado: (2018)

Nomograms for predicting the prognostic value of serological tumor biomarkers in colorectal cancer patients after radical resection
por: Li, Qingguo, et al.
Publicado: (2017)

Lnc-RP11-536 K7.3/SOX2/HIF-1α signaling axis regulates oxaliplatin resistance in patient-derived colorectal cancer organoids
por: Li, Qingguo, et al.
Publicado: (2021)

Prognostic impact of programed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor infiltrating lymphocytes in colorectal cancer
por: Li, Yaqi, et al.
Publicado: (2016)

Adjuvant radiotherapy improves cause specific survival in stage II, not stage III mucinous carcinoma of the rectum
por: Li, Qingguo, et al.
Publicado: (2017)

Development and external validation of a predictive scoring system associated with metastasis of T1‐2 colorectal tumors to lymph nodes
por: Mo, Shaobo, et al.
Publicado: (2020)

PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism
por: Dai, Weixing, et al.
Publicado: (2022)

GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies
por: Dai, Weixing, et al.
Publicado: (2020)

Comprehensive Transcriptomic Analysis Reveals Prognostic Value of an EMT-Related Gene Signature in Colorectal Cancer
por: Mo, Shaobo, et al.
Publicado: (2021)

Antisense lncRNA LDLRAD4-AS1 promotes metastasis by decreasing the expression of LDLRAD4 and predicts a poor prognosis in colorectal cancer
por: Mo, Shaobo, et al.
Publicado: (2020)

Lymph node status as a prognostic factor after palliative resection of primary tumor for patients with metastatic colorectal cancer
por: Li, Qingguo, et al.
Publicado: (2017)

The influence of marital status on stage at diagnosis and survival of patients with colorectal cancer
por: Li, Qingguo, et al.
Publicado: (2015)

SCF(FBW7)-mediated degradation of Brg1 suppresses gastric cancer metastasis
por: Huang, Li-Yu, et al.
Publicado: (2018)

Circulating basophil count as a prognostic marker of tumor aggressiveness and survival outcomes in colorectal cancer
por: Liu, Qi, et al.
Publicado: (2020)

Ferroptosis-associated molecular classification characterized by distinct tumor microenvironment profiles in colorectal cancer
por: Luo, Wenqin, et al.
Publicado: (2022)

Survival Benefit of Preoperative Versus Postoperative Radiotherapy in Metastatic Rectal Cancer Treated With Definitive Surgical Resection of Primary Tumor: A Population Based, Propensity Score-Matched Study
por: Luo, Dakui, et al.
Publicado: (2019)

The correlation between tumor size, lymph node status, distant metastases and mortality in rectal cancer patients without neoadjuvant therapy
por: Luo, Dakui, et al.
Publicado: (2021)

PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis
por: Qin, Yi, et al.
Publicado: (2019)

A robust gene signature for the prediction of early relapse in stage I–III colon cancer
por: Dai, Weixing, et al.
Publicado: (2018)

Survival Contradiction Between Stage IIA and Stage IIIA Rectal Cancer: A Retrospective Study
por: Mo, Shaobo, et al.
Publicado: (2018)

Stromal CEACAM1 expression regulates colorectal cancer metastasis
por: Arabzadeh, Azadeh, et al.
Publicado: (2012)

Pathological nodal staging score for rectal cancer patients treated with radical surgery with or without neoadjuvant therapy: a postoperative decision tool
por: Dai, Weixing, et al.
Publicado: (2019)

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer
por: Khan, Omar M., et al.
Publicado: (2018)

Evaluating the Guiding Role of Elevated Pretreatment Serum Carcinoembryonic Antigen Levels for Adjuvant Chemotherapy in Stage IIA Colon Cancer: A Large Population-Based and Propensity Score-Matched Study
por: Liu, Qi, et al.
Publicado: (2019)

Loss of Yes-associated Protein Represents an Aggressive Subtype of Colorectal Cancer
por: Zhang, Sheng, et al.
Publicado: (2019)

HER2 status is positively associated with vessel invasion of colorectal cancer: a retrospective large cohort study
por: Wang, Mingdian, et al.
Publicado: (2022)

Human oral microbiome dysbiosis as a novel non-invasive biomarker in detection of colorectal cancer
por: Zhang, Sheng, et al.
Publicado: (2020)

Immunohistochemistry‐Based Consensus Molecular Subtypes as a Prognostic and Predictive Biomarker for Adjuvant Chemotherapy in Patients with Stage II Colorectal Cancer
por: Li, Yaqi, et al.
Publicado: (2020)

Negative to positive lymph node ratio is a superior predictor than traditional lymph node status in stage III colorectal cancer
por: Li, Qingguo, et al.
Publicado: (2016)

Evaluation of Traditional Prognostic Factors for Stage I-III Colorectal Cancer Patients Who Survived for Over Five Years After Surgery
por: Luo, Dakui, et al.
Publicado: (2021)

FOXE1 represses cell proliferation and Warburg effect by inhibiting HK2 in colorectal cancer
por: Dai, Weixing, et al.
Publicado: (2020)

Enhanced De Novo Lipid Synthesis Mediated by FASN Induces Chemoresistance in Colorectal Cancer
por: Han, Lingyu, et al.
Publicado: (2023)

Prognostic nomograms for predicting cause-specific survival and overall survival of stage I–III colon cancer patients: a large population-based study
por: Zhou, Zheng, et al.
Publicado: (2019)

Clinicopathological Features of Stage I–III Colorectal Cancer Recurrence Over 5 Years After Radical Surgery Without Receiving Neoadjuvant Therapy: Evidence From a Large Sample Study
por: Luo, Dakui, et al.
Publicado: (2021)

Establishment and validation of a novel nomogram incorporating clinicopathological parameters into the TNM staging system to predict prognosis for stage II colorectal cancer
por: Mo, Shaobo, et al.
Publicado: (2020)

Patient-derived organoids as a platform for drug screening in metastatic colorectal cancer
por: He, Xingfeng, et al.
Publicado: (2023)

P–TNM staging system for colon cancer: combination of P-stage and AJCC TNM staging system for improving prognostic prediction and clinical management
por: Liu, Qi, et al.
Publicado: (2018)

Real-World Implications of Nonbiological Factors with Staging, Prognosis and Clinical Management in Colon Cancer
por: Liu, Qi, et al.
Publicado: (2018)

Circumferential resection margin as a prognostic factor after rectal cancer surgery: A large population‐based retrospective study
por: Liu, Qi, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3b84fvggasf7hnievdv2nccg2a