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Structures and disulfide cross‐linking of de novo designed therapeutic mini‐proteins

Recent advances in computational protein design now enable the massively parallel de novo design and experimental characterization of small hyperstable binding proteins with potential therapeutic activity. By providing experimental feedback on tens of thousands of designed proteins, the design‐build...

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Detalles Bibliográficos
Autores principales: Silva, Daniel‐Adriano, Stewart, Lance, Lam, Kwok‐Ho, Jin, Rongsheng, Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001749/
https://www.ncbi.nlm.nih.gov/pubmed/29389072
http://dx.doi.org/10.1111/febs.14394