Cargando…

Identifying Small‐Molecule Binding Sites for Epigenetic Proteins at Domain–Domain Interfaces

Epigenetics is a rapidly growing field in drug discovery. Of particular interest is the role of post‐translational modifications to histones and the proteins that read, write, and erase such modifications. The development of inhibitors for reader domains has focused on single domains. One of the maj...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bowkett, David, Talon, Romain, Tallant, Cynthia, Schofield, Chris, von Delft, Frank, Knapp, Stefan, Bruton, Gordon, Brennan, Paul E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001751/ https://www.ncbi.nlm.nih.gov/pubmed/29578648 http://dx.doi.org/10.1002/cmdc.201800030

Ejemplares similares

Crystal structures of human soluble guanylate cyclase catalytic domains: promiscuity of the dimer interface and a potential allosteric site
por: Gileadi, Opher, et al.
Publicado: (2013)

Domain-based small molecule binding site annotation
por: Snyder, Kevin A, et al.
Publicado: (2006)

The MECP2‐TRD domain interacts with the DNMT3A‐ADD domain at the H3‐tail binding site
por: Kunert, Stefan, et al.
Publicado: (2023)

Characterization of spherical domains at the polystyrene thin film–water interface
por: Ahmad, Khurshid, et al.
Publicado: (2016)

Synthesis and Demonstration of the Biological Relevance of sp(3)‐rich Scaffolds Distantly Related to Natural Product Frameworks
por: Foley, Daniel J., et al.
Publicado: (2017)

A High‐Affinity Calmodulin‐Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells
por: Voegele, Alexis, et al.
Publicado: (2021)

Identification of Small Molecule Ligand Binding Sites On and In the ARNT PAS-B Domain
por: Xu, Xingjian, et al.
Publicado: (2023)

The Allosteric Site on SHP2’s Protein Tyrosine Phosphatase Domain is Targetable with Druglike Small Molecules
por: Marsh-Armstrong, Brennan, et al.
Publicado: (2018)

Ferroelectric Domain Wall Memristor
por: McConville, James P. V., et al.
Publicado: (2020)

Metal Exchange in the Interprotein Zn(II)‐Binding Site of the Rad50 Hook Domain: Structural Insights into Cd(II)‐Induced DNA‐Repair Inhibition
por: Padjasek, Michał, et al.
Publicado: (2020)

Crystal Structures of the Catalytic Domain of Human Soluble Guanylate Cyclase
por: Allerston, Charles K., et al.
Publicado: (2013)

A comparison of the binding sites of antibodies and single-domain antibodies
por: Gordon, Gemma L., et al.
Publicado: (2023)

Unraveling the structural landscape of intra-chain domain interfaces: Implication in the evolution of domain-domain interactions
por: Verma, Rivi, et al.
Publicado: (2019)

The domain interface method in non-conforming domain decomposition multifield problems
por: Lloberas-Valls, O., et al.
Publicado: (2016)

Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B
por: Skaist Mehlman, Tamar, et al.
Publicado: (2023)

Inhibition of the EGF Receptor by Binding to an Activating Kinase Domain Interface
por: Zhang, Xuewu, et al.
Publicado: (2007)

Mapping small molecule binding data to structural domains
por: Kruger, Felix A, et al.
Publicado: (2012)

Structural features of the protein kinase domain and targeted binding by small-molecule inhibitors
por: Arter, Chris, et al.
Publicado: (2022)

Constant domain polymorphisms influence monoclonal antibody stability and dynamics
por: Warrender, Annmaree K., et al.
Publicado: (2023)

Mapping the Binding Interface of PET Tracer Molecules and Alzheimer Disease Aβ Fibrils by Using MAS Solid‐State NMR Spectroscopy
por: Niu, Zheng, et al.
Publicado: (2020)

A Biomimetic Approach toward Enhancing Angiogenesis: Recombinantly Expressed Domain V of Human Perlecan Is a Bioactive Molecule That Promotes Angiogenesis and Vascularization of Implanted Biomaterials
por: Lin, Xiaoting, et al.
Publicado: (2020)

The crystal structure of TRPM2 MHR1/2 domain reveals a conserved Zn(2+)‐binding domain essential for structural integrity and channel activity
por: Sander, Simon, et al.
Publicado: (2022)

Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension
por: Chaikuad, Apirat, et al.
Publicado: (2019)

In the Multi-domain Protein Adenylate Kinase, Domain Insertion Facilitates Cooperative Folding while Accommodating Function at Domain Interfaces
por: Giri Rao, V. V. Hemanth, et al.
Publicado: (2014)

Comprehensive 3D‐RISM analysis of the hydration of small molecule binding sites in ligand‐free protein structures
por: Yoshidome, Takashi, et al.
Publicado: (2020)

Native interface of the SAM domain polymer of TEL
por: Tran, Hoang H, et al.
Publicado: (2002)

Structural and Functional Analysis of Multi-Interface Domains
por: Zhao, Liang, et al.
Publicado: (2012)

Epigenetic response of imprinted domains during carcinogenesis
por: Bretz, Corey L., et al.
Publicado: (2017)

In silico identification of strong binders of the SARS-CoV-2 receptor-binding domain
por: Behloul, Nouredine, et al.
Publicado: (2021)

Determining folding and binding properties of the C‐terminal SH2 domain of SHP2
por: Nardella, Caterina, et al.
Publicado: (2021)

PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain
por: Li, Yamu, et al.
Publicado: (2022)

The IKK-binding domain of NEMO is an irregular coiled coil with a dynamic binding interface
por: Barczewski, Adam H., et al.
Publicado: (2019)

Out of the Box Binding Determines Specificity of SH2 Domain Interaction
por: Müller, Susanne, et al.
Publicado: (2009)

Contribution of Streptokinase-Domains from Groups G and A (SK2a) Streptococci in Amidolytic/Proteolytic Activities and Fibrin-Dependent Plasminogen Activation: A Domain-Exchange Study
por: Rafipour, Maryam, et al.
Publicado: (2020)

Completing the family of human Eps15 homology domains: Solution structure of the internal Eps15 homology domain of γ‐synergin
por: Kovermann, Michael, et al.
Publicado: (2022)

Docking-based identification of small-molecule binding sites at protein-protein interfaces
por: Rosell, Mireia, et al.
Publicado: (2020)

Ligand binding and global adaptation of the GlnPQ substrate binding domain 2 revealed by molecular dynamics simulations
por: Kienlein, Maximilian, et al.
Publicado: (2020)

Insights into the conformation changes of SARS-CoV-2 spike receptor-binding domain on graphene
por: Du, Jianbin, et al.
Publicado: (2022)

Activated endothelium binds lymphocytes through a novel binding site in the alternately spliced domain of vascular cell adhesion molecule-1
Publicado: (1992)

EPR Characterisation of the Ferrous Nitrosyl Complex Formed within the Oxygenase Domain of NO Synthase
por: Santolini, Jérôme, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_176rhn9ji11n6d24b33cg2ji5l