Aging‐associated changes in hippocampal glycogen metabolism in mice. Evidence for and against astrocyte‐to‐neuron lactate shuttle

Lactate derived from astrocytic glycogen has been shown to support memory formation in hippocampi of young animals, inhibiting it in old animals. Here we show, using quantitative mass spectrometry‐based proteomics, immunofluorescence, and qPCR that aging is associated with an increase of glycogen me...

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Detalles Bibliográficos
Autores principales: Drulis‐Fajdasz, Dominika, Gizak, Agnieszka, Wójtowicz, Tomasz, Wiśniewski, Jacek R., Rakus, Dariusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001795/
https://www.ncbi.nlm.nih.gov/pubmed/29493012
http://dx.doi.org/10.1002/glia.23319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001795/
https://www.ncbi.nlm.nih.gov/pubmed/29493012
http://dx.doi.org/10.1002/glia.23319

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