11Beta‐hydroxysteroid dehydrogenase‐1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis

A hallmark of chronic liver injury is fibrosis, with accumulation of extracellular matrix orchestrated by activated hepatic stellate cells (HSCs). Glucocorticoids limit HSC activation in vitro, and tissue glucocorticoid levels are amplified by 11beta‐hydroxysteroid dehydrogenase‐1 (11βHSD1). Althoug...

Descripción completa

Detalles Bibliográficos
Autores principales: Zou, Xiantong, Ramachandran, Prakash, Kendall, Timothy J., Pellicoro, Antonella, Dora, Elena, Aucott, Rebecca L., Manwani, Kajal, Man, Tak Yung, Chapman, Karen E., Henderson, Neil C., Forbes, Stuart J., Webster, Scott P., Iredale, John P., Walker, Brian R., Michailidou, Zoi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001805/
https://www.ncbi.nlm.nih.gov/pubmed/29251794
http://dx.doi.org/10.1002/hep.29734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001805/
https://www.ncbi.nlm.nih.gov/pubmed/29251794
http://dx.doi.org/10.1002/hep.29734

Ejemplares similares