Enzyme Architecture: The Role of a Flexible Loop in Activation of Glycerol-3-phosphate Dehydrogenase for Catalysis of Hydride Transfer

[Image: see text] The side chain of Q295 of glycerol-3-phosphate dehydrogenase from human liver (hlGPDH) lies in a flexible loop, that folds over the phosphodianion of substrate dihydroxyacetone phosphate (DHAP). Q295 interacts with the side-chain cation from R269, which is ion-paired to the substra...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Rui, Reyes, Archie C., Amyes, Tina L., Richard, John P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001809/
https://www.ncbi.nlm.nih.gov/pubmed/29337541
http://dx.doi.org/10.1021/acs.biochem.7b01282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001809/
https://www.ncbi.nlm.nih.gov/pubmed/29337541
http://dx.doi.org/10.1021/acs.biochem.7b01282

Ejemplares similares