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Enzyme Architecture: The Role of a Flexible Loop in Activation of Glycerol-3-phosphate Dehydrogenase for Catalysis of Hydride Transfer

[Image: see text] The side chain of Q295 of glycerol-3-phosphate dehydrogenase from human liver (hlGPDH) lies in a flexible loop, that folds over the phosphodianion of substrate dihydroxyacetone phosphate (DHAP). Q295 interacts with the side-chain cation from R269, which is ion-paired to the substra...

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Detalles Bibliográficos
Autores principales:	He, Rui, Reyes, Archie C., Amyes, Tina L., Richard, John P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001809/ https://www.ncbi.nlm.nih.gov/pubmed/29337541 http://dx.doi.org/10.1021/acs.biochem.7b01282

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