Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer

Several members of the sirtuin (SIRT) family, a highly conserved family of NAD(+)-dependent enzymes, have been shown to play a critical role in both promoting and/or suppressing tumorigenesis. In this study, recent progress in the field concerning SIRT4 and cancer was reviewed, and the relationship...

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Detalles Bibliográficos
Autores principales: Huang, Guoyu, Zhu, Guanbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001835/
https://www.ncbi.nlm.nih.gov/pubmed/29928130
http://dx.doi.org/10.2147/OTT.S157724
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author Huang, Guoyu
Zhu, Guanbao
author_facet Huang, Guoyu
Zhu, Guanbao
author_sort Huang, Guoyu
collection PubMed
description Several members of the sirtuin (SIRT) family, a highly conserved family of NAD(+)-dependent enzymes, have been shown to play a critical role in both promoting and/or suppressing tumorigenesis. In this study, recent progress in the field concerning SIRT4 and cancer was reviewed, and the relationship between SIRT4 and tumors was investigated. Subsequently, we evaluated the role of SIRT4 with oncogenic or tumor-suppressive activity in cancer, which may provide insight in identifying the underlying mechanism of action of SIRT4 in cancer. Finally, we explored the potential of SIRT4 as a therapeutic target in cancer therapy.
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spelling pubmed-60018352018-06-20 Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer Huang, Guoyu Zhu, Guanbao Onco Targets Ther Review Several members of the sirtuin (SIRT) family, a highly conserved family of NAD(+)-dependent enzymes, have been shown to play a critical role in both promoting and/or suppressing tumorigenesis. In this study, recent progress in the field concerning SIRT4 and cancer was reviewed, and the relationship between SIRT4 and tumors was investigated. Subsequently, we evaluated the role of SIRT4 with oncogenic or tumor-suppressive activity in cancer, which may provide insight in identifying the underlying mechanism of action of SIRT4 in cancer. Finally, we explored the potential of SIRT4 as a therapeutic target in cancer therapy. Dove Medical Press 2018-06-11 /pmc/articles/PMC6001835/ /pubmed/29928130 http://dx.doi.org/10.2147/OTT.S157724 Text en © 2018 Huang and Zhu. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Huang, Guoyu
Zhu, Guanbao
Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer
title Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer
title_full Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer
title_fullStr Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer
title_full_unstemmed Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer
title_short Sirtuin-4 (SIRT4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer
title_sort sirtuin-4 (sirt4), a therapeutic target with oncogenic and tumor-suppressive activity in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001835/
https://www.ncbi.nlm.nih.gov/pubmed/29928130
http://dx.doi.org/10.2147/OTT.S157724
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