Short-term Low-Dose mTORC1 Inhibition in Aged Rats Counter-Regulates Age-Related Gene Changes and Blocks Age-Related Kidney Pathology

Rapalogs, inhibitors of mTORC1 (mammalian target of rapamycin complex 1), increase life span and delay age-related phenotypes in many species. However, the molecular mechanisms have not been fully elucidated. We determined gene expression changes comparing 6- and 24-month-old rats in the kidney, liv...

Descripción completa

Detalles Bibliográficos
Autores principales: Shavlakadze, Tea, Zhu, Jiang, Wang, Sharon, Zhou, Weihua, Morin, Bret, Egerman, Marc A, Fan, Lin, Wang, Yanqun, Iartchouk, Oleg, Meyer, Angelika, Valdez, Reginald A, Mannick, Joan B, Klickstein, Lloyd B, Glass, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
The Journal of Gerontology: Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001891/
https://www.ncbi.nlm.nih.gov/pubmed/29304191
http://dx.doi.org/10.1093/gerona/glx249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001891/
https://www.ncbi.nlm.nih.gov/pubmed/29304191
http://dx.doi.org/10.1093/gerona/glx249

Ejemplares similares