Mutations in the voltage‐sensing domain affect the alternative ion permeation pathway in the TRPM3 channel

KEY POINTS: Mutagenesis at positively charged amino acids (arginines and lysines) (R1–R4) in the voltage‐sensor domain (transmembrane segment (S) 4) of voltage‐gated Na(+), K(+) and Ca(2+) channels can lead to an alternative ion permeation pathway distinct from the central pore. Recently, a non‐cano...

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Detalles Bibliográficos
Autores principales: Held, Katharina, Gruss, Fabian, Aloi, Vincenzo Davide, Janssens, Annelies, Ulens, Chris, Voets, Thomas, Vriens, Joris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002228/
https://www.ncbi.nlm.nih.gov/pubmed/29604058
http://dx.doi.org/10.1113/JP274124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002228/
https://www.ncbi.nlm.nih.gov/pubmed/29604058
http://dx.doi.org/10.1113/JP274124

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