Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

A recently developed adenine base editor (ABE) efficiently converts A to G and is potentially useful for clinical applications. However, its precision and efficiency in vivo remains to be addressed. Here we achieve A-to-G conversion in vivo at frequencies up to 100% by microinjection of ABE mRNA tog...

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Detalles Bibliográficos
Autores principales: Liu, Zhen, Lu, Zongyang, Yang, Guang, Huang, Shisheng, Li, Guanglei, Feng, Songjie, Liu, Yajing, Li, Jianan, Yu, Wenxia, Zhang, Yu, Chen, Jia, Sun, Qiang, Huang, Xingxu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002399/
https://www.ncbi.nlm.nih.gov/pubmed/29904106
http://dx.doi.org/10.1038/s41467-018-04768-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002399/
https://www.ncbi.nlm.nih.gov/pubmed/29904106
http://dx.doi.org/10.1038/s41467-018-04768-7

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