Cargando…

Inhibitory influence of natural flavonoids on human protein kinase CK2 isoforms: effect of the regulatory subunit

CK2 is a pleiotropic, constitutively active protein kinase responsible for the phosphorylation of more than 300 physiological substrates. Typically, this enzyme is found in tetrameric form consisting of two regulatory subunits CK2β and two catalytic subunits CK2α or CK2α′. Several natural occurring...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baier, Andrea, Nazaruk, Jolanta, Galicka, Anna, Szyszka, Ryszard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002439/ https://www.ncbi.nlm.nih.gov/pubmed/29188536 http://dx.doi.org/10.1007/s11010-017-3228-1

Ejemplares similares

CK2 and protein kinases of the CK1 superfamily as targets for neurodegenerative disorders
por: Baier, Andrea, et al.
Publicado: (2022)

Yeast Protein Asf1 Possesses Modulating Activity towards Protein Kinase CK2
por: Baier, Andrea, et al.
Publicado: (2022)

Compounds from Natural Sources as Protein Kinase Inhibitors
por: Baier, Andrea, et al.
Publicado: (2020)

The Multiple Personalities of the Regulatory Subunit of Protein Kinase CK2: CK2 Dependent and CK2 Independent Roles Reveal a Secret Identity for CK2β
por: Bibby, Ashley C., et al.
Publicado: (2005)

Inhibitory Activity of Flavonoids against Class I Phosphatidylinositol 3-Kinase Isoforms
por: Kong, Dexin, et al.
Publicado: (2011)

Anethole prevents hydrogen peroxide-induced apoptosis and collagen metabolism alterations in human skin fibroblasts
por: Galicka, Anna, et al.
Publicado: (2014)

Protein kinase CK2α subunits constitutively activate ABA signaling in Arabidopsis
por: Nagatoshi, Yukari, et al.
Publicado: (2018)

The regulatory subunits of CK2 complex mediate DNA damage response and virulence in Candida Glabrata
por: Ni, Qi, et al.
Publicado: (2023)

Overexpression of Nuclear Protein Kinase CK2 α Catalytic Subunit (CK2α) as a Poor Prognosticator in Human Colorectal Cancer
por: Lin, Kai-Yuan, et al.
Publicado: (2011)

Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks
por: Nuñez de Villavicencio-Diaz, Teresa, et al.
Publicado: (2017)

Characterizing the convergence of protein kinase CK2 and caspase-3 reveals isoform-specific phosphorylation of caspase-3 by CK2α′: implications for pathological roles of CK2 in promoting cancer cell survival
por: Turowec, Jacob P., et al.
Publicado: (2013)

The Immune Regulatory Role of Protein Kinase CK2 and Its Implications for Treatment of Cancer
por: Hong, Huixian, et al.
Publicado: (2021)

Synthesis of Novel Halogenated Heterocycles Based on o-Phenylenediamine and Their Interactions with the Catalytic Subunit of Protein Kinase CK2
por: Winiewska-Szajewska, Maria, et al.
Publicado: (2021)

More precise prediction in Chinese patients with penile squamous cell carcinoma: protein kinase CK2α catalytic subunit (CK2α) as a poor prognosticator
por: Li, Zai-Shang, et al.
Publicado: (2017)

Drosophila Protein Kinase CK2: Genetics, Regulatory Complexity and Emerging Roles during Development
por: Bandyopadhyay, Mohna, et al.
Publicado: (2016)

Contribution of the CK2 Catalytic Isoforms α and α’ to the Glycolytic Phenotype of Tumor Cells
por: Zonta, Francesca, et al.
Publicado: (2021)

Targeting Protein Kinases in Blood Cancer: Focusing on CK1α and CK2
por: Spinello, Zaira, et al.
Publicado: (2021)

Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α′
por: Hochscherf, Jennifer, et al.
Publicado: (2017)

Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms
por: Søberg, Kristoffer, et al.
Publicado: (2017)

Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma
por: Zhang, Hong-Xia, et al.
Publicado: (2015)

Ablation of beta subunit of protein kinase CK2 in mouse oocytes causes follicle atresia and premature ovarian failure
por: Liang, Qiu-Xia, et al.
Publicado: (2018)

Malaria Protein Kinase CK2 (PfCK2) Shows Novel Mechanisms of Regulation
por: Graciotti, Michele, et al.
Publicado: (2014)

Protein Kinase CK2 in Cancer Energetics
por: Silva-Pavez, Eduardo, et al.
Publicado: (2020)

Protein kinase A regulatory subunit distribution in medulloblastoma
por: Mucignat-Caretta, Carla, et al.
Publicado: (2010)

The FAM83 family of proteins: from pseudo-PLDs to anchors for CK1 isoforms
por: Bozatzi, Polyxeni, et al.
Publicado: (2018)

In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface
por: Bestgen, Benoît, et al.
Publicado: (2017)

Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cells
por: Kreutzer, Jan N, et al.
Publicado: (2010)

Protein Kinase CK2 Subunits Differentially Perturb the Adhesion and Migration of GN11 Cells: A Model of Immature Migrating Neurons
por: Lettieri, Antonella, et al.
Publicado: (2019)

Halogen Atoms in the Protein–Ligand System. Structural and Thermodynamic Studies of the Binding of Bromobenzotriazoles by the Catalytic Subunit of Human Protein Kinase CK2
por: Czapinska, Honorata, et al.
Publicado: (2021)

Role of Plant-Specific N-Terminal Domain of Maize CK2β1 Subunit in CK2β Functions and Holoenzyme Regulation
por: Riera, Marta, et al.
Publicado: (2011)

Protein kinase CK2 and ion channels (Review)
por: Montenarh, Mathias, et al.
Publicado: (2020)

Targeting protein kinase CK2 in the treatment of cholangiocarcinoma
por: Jayaraman, Padma-Sheela, et al.
Publicado: (2021)

Protein Kinase CK2 and Epstein–Barr Virus
por: Montenarh, Mathias, et al.
Publicado: (2023)

Glycogen Synthase Kinase-3 Isoform Variants and Their Inhibitory Phosphorylation in Human Testes and Spermatozoa
por: Park, Seung Hyun, et al.
Publicado: (2023)

Influence of GABA(A) Receptor α Subunit Isoforms on the Benzodiazepine Binding Site
por: Lüscher, Benjamin P., et al.
Publicado: (2012)

Natural Compounds Isolated from Stachybotrys chartarum Are Potent Inhibitors of Human Protein Kinase CK2
por: Haidar, Samer, et al.
Publicado: (2021)

The Creatine Kinase/Creatine Connection to Alzheimer's Disease: CK Inactivation, APP-CK Complexes, and Focal Creatine Deposits
por: Bürklen, Tanja S., et al.
Publicado: (2006)

Macro-CK and CK-BB Contributing to Sham CK-MB Elevation
por: Wada, Yuki, et al.
Publicado: (2017)

Assessing the Inhibitory Potential of Kinase Inhibitors In Vitro: Major Pitfalls and Suggestions for Improving Comparability of Data Using CK1 Inhibitors as an Example
por: Roth, Aileen, et al.
Publicado: (2021)

The Link between Protein Kinase CK2 and Atypical Kinase Rio1
por: Kubiński, Konrad, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_0eumv1ian1og76c5ng1rsheacm