Applying a Global Sensitivity Analysis Workflow to Improve the Computational Efficiencies in Physiologically-Based Pharmacokinetic Modeling

Traditionally, the solution to reduce parameter dimensionality in a physiologically-based pharmacokinetic (PBPK) model is through expert judgment. However, this approach may lead to bias in parameter estimates and model predictions if important parameters are fixed at uncertain or inappropriate valu...

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Detalles Bibliográficos
Autores principales: Hsieh, Nan-Hung, Reisfeld, Brad, Bois, Frederic Y., Chiu, Weihsueh A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002508/
https://www.ncbi.nlm.nih.gov/pubmed/29937730
http://dx.doi.org/10.3389/fphar.2018.00588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002508/
https://www.ncbi.nlm.nih.gov/pubmed/29937730
http://dx.doi.org/10.3389/fphar.2018.00588

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