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Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24, -2 protein secretion

BACKGROUND: Increasing evidence reveals a significant correlation between gamma-synuclein (SNCG) level and tumor invasion and metastasis in various human cancers. Our previous investigation showed that SNCG could secrete into extracellular environment and promoted tumor cell motility, but the mechan...

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Detalles Bibliográficos
Autores principales: Liu, Caiyun, Qu, Like, Zhao, Chuanke, Shou, Chengchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003176/
https://www.ncbi.nlm.nih.gov/pubmed/29903032
http://dx.doi.org/10.1186/s13046-018-0783-6