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Extant fold-switching proteins are widespread

A central tenet of biology is that globular proteins have a unique 3D structure under physiological conditions. Recent work has challenged this notion by demonstrating that some proteins switch folds, a process that involves remodeling of secondary structure in response to a few mutations (evolved f...

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Detalles Bibliográficos
Autores principales: Porter, Lauren L., Looger, Loren L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003340/
https://www.ncbi.nlm.nih.gov/pubmed/29784778
http://dx.doi.org/10.1073/pnas.1800168115