Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice

MTOR (mechanistic target of rapamycin) is a widely recognized integrator of signals and pathways key for cellular metabolism, proliferation, and differentiation. Here we show that conditional knockout (cKO) of Mtor in either primordial or growing oocytes caused infertility but differentially affecte...

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Detalles Bibliográficos
Autores principales: Guo, Jing, Zhang, Teng, Guo, Yueshuai, Sun, Tao, Li, Hui, Zhang, Xiaoyun, Yin, Hong, Cao, Guangyi, Yin, Yaoxue, Wang, Hao, Shi, Lanying, Guo, Xuejiang, Sha, Jiahao, Eppig, John J., Su, You-Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003357/
https://www.ncbi.nlm.nih.gov/pubmed/29784807
http://dx.doi.org/10.1073/pnas.1800352115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003357/
https://www.ncbi.nlm.nih.gov/pubmed/29784807
http://dx.doi.org/10.1073/pnas.1800352115

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