Suppressor mutation analysis combined with 3D modeling explains cohesin’s capacity to hold and release DNA

Cohesin is a fundamental protein complex that holds sister chromatids together. Separase protease cleaves a cohesin subunit Rad21/SCC1, causing the release of cohesin from DNA to allow chromosome segregation. To understand the functional organization of cohesin, we employed next-generation whole-gen...

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Detalles Bibliográficos
Autores principales: Xu, Xingya, Kanai, Ryuta, Nakazawa, Norihiko, Wang, Li, Toyoshima, Chikashi, Yanagida, Mitsuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003501/
https://www.ncbi.nlm.nih.gov/pubmed/29735656
http://dx.doi.org/10.1073/pnas.1803564115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003501/
https://www.ncbi.nlm.nih.gov/pubmed/29735656
http://dx.doi.org/10.1073/pnas.1803564115

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