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Suppressor mutation analysis combined with 3D modeling explains cohesin’s capacity to hold and release DNA
Cohesin is a fundamental protein complex that holds sister chromatids together. Separase protease cleaves a cohesin subunit Rad21/SCC1, causing the release of cohesin from DNA to allow chromosome segregation. To understand the functional organization of cohesin, we employed next-generation whole-gen...
Autores principales: | Xu, Xingya, Kanai, Ryuta, Nakazawa, Norihiko, Wang, Li, Toyoshima, Chikashi, Yanagida, Mitsuhiro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003501/ https://www.ncbi.nlm.nih.gov/pubmed/29735656 http://dx.doi.org/10.1073/pnas.1803564115 |
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