High mobility group A2 (HMGA2) deficiency in pigs leads to dwarfism, abnormal fetal resource allocation, and cryptorchidism

Expression of HMGA2 is strongly associated with body size and growth in mice and humans. In mice, inactivation of one or both alleles of Hmga2 results in body-size reductions of 20% and 60%, respectively. In humans, microdeletions involving the HMGA2 locus result in short stature, suggesting the fun...

Descripción completa

Detalles Bibliográficos
Autores principales: Chung, Jaewook, Zhang, Xia, Collins, Bruce, Sper, Renan B., Gleason, Katherine, Simpson, Sean, Koh, Sehwon, Sommer, Jeffrey, Flowers, William L., Petters, Robert M., Piedrahita, Jorge A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003518/
https://www.ncbi.nlm.nih.gov/pubmed/29735702
http://dx.doi.org/10.1073/pnas.1721630115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003518/
https://www.ncbi.nlm.nih.gov/pubmed/29735702
http://dx.doi.org/10.1073/pnas.1721630115

Ejemplares similares