SMAD proteins directly suppress PAX2 transcription downstream of transforming growth factor-beta 1 (TGF-β1) signalling in renal cell carcinoma

Canonical TGF-β1 signalling promotes tumor progression by facilitating invasion and metastasis, whereby release of TGF-β1, by (for example) infiltrating immune cells, induces epithelial to mesenchymal transition (EMT). PAX2, a member of the Paired box family of transcriptional regulators, is normall...

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Detalles Bibliográficos
Autores principales: Kaur, Gagandeep, Li, Caiyun Grace, Chantry, Andrew, Stayner, Cherie, Horsfield, Julia, Eccles, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003550/
https://www.ncbi.nlm.nih.gov/pubmed/29928489
http://dx.doi.org/10.18632/oncotarget.25516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003550/
https://www.ncbi.nlm.nih.gov/pubmed/29928489
http://dx.doi.org/10.18632/oncotarget.25516

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