Cargando…

SMAD proteins directly suppress PAX2 transcription downstream of transforming growth factor-beta 1 (TGF-β1) signalling in renal cell carcinoma

Canonical TGF-β1 signalling promotes tumor progression by facilitating invasion and metastasis, whereby release of TGF-β1, by (for example) infiltrating immune cells, induces epithelial to mesenchymal transition (EMT). PAX2, a member of the Paired box family of transcriptional regulators, is normall...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaur, Gagandeep, Li, Caiyun Grace, Chantry, Andrew, Stayner, Cherie, Horsfield, Julia, Eccles, Michael R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003550/ https://www.ncbi.nlm.nih.gov/pubmed/29928489 http://dx.doi.org/10.18632/oncotarget.25516

Ejemplares similares

The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter
por: Grocott, Timothy, et al.
Publicado: (2007)

Chemical Synthesis of the PAX Protein Inhibitor EG1 and Its Ability to Slow the Growth of Human Colorectal Carcinoma Cells
por: McDougall, Lorissa, et al.
Publicado: (2021)

PAX Genes in Cancer; Friends or Foes?
por: Li, Caiyun G., et al.
Publicado: (2012)

Polycystic kidney disease – where gene dosage counts
por: Eccles, Michael R., et al.
Publicado: (2014)

TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling
por: Hough, Chris, et al.
Publicado: (2012)

Possible involvement of TGF-β-SMAD-mediated epithelial-mesenchymal transition in pro-metastatic property of PAX6
por: Jin, Meng, et al.
Publicado: (2020)

Aspirin attenuates liver fibrosis by suppressing TGF-β1/Smad signaling
por: Sun, Yimin, et al.
Publicado: (2022)

Co-Expression of Multiple PAX Genes in Renal Cell Carcinoma (RCC) and Correlation of High PAX Expression with Favorable Clinical Outcome in RCC Patients
por: Li, Lei, et al.
Publicado: (2023)

Expression of transforming growth factor beta (TGF beta) receptors and expression of TGF beta 1, TGF beta 2 and TGF beta 3 in human small cell lung cancer cell lines.
por: Damstrup, L., et al.
Publicado: (1993)

Participation of the SMAD2/3 signalling pathway in the down regulation of megalin/LRP2 by transforming growth factor beta (TGF-ß1)
por: Cabezas, Felipe, et al.
Publicado: (2019)

TGF beta1 and related-Smads contribute to pulmonary metastasis of hepatocellular carcinoma in mice model
por: Li, Guo-Cai, et al.
Publicado: (2012)

Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs
por: Manceau, Line, et al.
Publicado: (2022)

Aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway in intrauterine adhesions
por: Zhang, Zihui, et al.
Publicado: (2020)

Non-coding RNAs as potential biomarkers and therapeutic targets in polycystic kidney disease
por: Zheng, Qi, et al.
Publicado: (2022)

Transforming Growth Factor Beta (TGF-β) Is a Muscle Biomarker of Disease Progression in ALS and Correlates with Smad Expression
por: Si, Ying, et al.
Publicado: (2015)

Immunoregulatory role of transforming growth factor beta (TGF-beta) in development of killer cells: comparison of active and latent TGF-beta 1
Publicado: (1990)

Long-range downstream enhancers are essential for Pax6 expression
por: Kleinjan, Dirk A., et al.
Publicado: (2006)

Role of TGF-Beta and Smad7 in Gut Inflammation, Fibrosis and Cancer
por: Stolfi, Carmine, et al.
Publicado: (2020)

Correction: Transcriptional factors Smad1 and Smad9 act redundantly to mediate zebrafish ventral specification downstream of Smad5.
por: Wei, Chang-Yong, et al.
Publicado: (2021)

Correction: Transcriptional factors smad1 and smad9 act redundantly to mediate zebrafish ventral specification downstream of smad5
por: Wei, Chang-Yong, et al.
Publicado: (2021)

Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia
Publicado: (1991)

Elevated plasma levels of transforming growth factor (TGF)-beta1 and TGF-beta2 in patients with disseminated malignant melanoma.
por: Krasagakis, K., et al.
Publicado: (1998)

Effects of Bone Marrow-Derived Mesenchymal Stem Cells on Hypoxia and the Transforming Growth Factor beta 1 (TGFβ-1) and SMADs Pathway in a Mouse Model of Cirrhosis
por: Zhang, Liting, et al.
Publicado: (2019)

Er81 is a downstream target of Pax6 in cortical progenitors
por: Tuoc, Tran Cong, et al.
Publicado: (2008)

BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor beta [TGF-β1] in colorectal tumour cells
por: Skeen, Victoria R., et al.
Publicado: (2012)

Adiponectin Modified BMSCs Alleviate Heart Fibrosis via Inhibition TGF-beta1/Smad in Diabetic Rats
por: Meng, Ke, et al.
Publicado: (2021)

HSV-1 infection suppresses TGF-β1 and SMAD3 expression in human corneal epithelial cells
por: Nie, Yuhong, et al.
Publicado: (2008)

Fus knockdown inhibits the profibrogenic effect of cardiac fibroblasts induced by angiotensin II through targeting Pax3 thereby regulating TGF-β1/Smad pathway
por: Wang, Guoqiang, et al.
Publicado: (2021)

Transforming growth factor beta1 (TGF-beta1) is a preoperative prognostic indicator in advanced gastric carcinoma.
por: Nakamura, M., et al.
Publicado: (1998)

TGF-β-Elicited Induction of Tissue Inhibitor of Metalloproteinases (TIMP)-3 Expression in Fibroblasts Involves Complex Interplay between Smad3, p38α, and ERK1/2
por: Leivonen, Suvi-Katri, et al.
Publicado: (2013)

Smad3 deficiency promotes beta cell proliferation and function in db/db mice via restoring Pax6 expression
por: Sheng, Jingyi, et al.
Publicado: (2021)

ITGBL1 transcriptionally inhibited by JDP2 promotes the development of pancreatic cancer through the TGF-beta/Smad pathway
por: Du, Tiancong, et al.
Publicado: (2022)

Corrigendum: Adiponectin modified BMSCs alleviate heart fibrosis via inhibition TGF-beta1/smad in diabetic rats
por: Meng, Ke, et al.
Publicado: (2023)

Alcohol Activates TGF-Beta but Inhibits BMP Receptor-Mediated Smad Signaling and Smad4 Binding to Hepcidin Promoter in the Liver
por: Gerjevic, Lisa Nicole, et al.
Publicado: (2012)

Increased transforming growth factor beta (TGF-β) and pSMAD3 signaling in a Murine Model for Contrast Induced Kidney Injury
por: Kilari, Sreenivasulu, et al.
Publicado: (2018)

Circular RNA HECTD1 knockdown inhibits transforming growth factor-beta/ small mothers against decapentaplegic (TGF-β/Smad) signaling to reduce hypertrophic scar fibrosis
por: Ge, Xiaojing, et al.
Publicado: (2022)

Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia
Publicado: (1990)

Age-Dependent Decrease in Serum Transforming Growth Factor (TGF)-Beta 1 in Healthy Japanese Individuals; Population Study of Serum TGF-Beta 1 Level in Japanese
por: Okamoto, Yoshihiro, et al.
Publicado: (2005)

Rejuvenation by inhibiting TGF-β1/pSmad signaling
por: Corder, Elizabeth H., et al.
Publicado: (2015)

Leucine rich alpha-2-glycoprotein 1 (Lrg1) silencing protects against sepsis-mediated brain injury by inhibiting transforming growth factor beta1 (TGFβ1)/SMAD signaling pathway
por: Miao, Youhan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_66bd6irq0ic2n0ah3otv0gl0ff