Klotho inhibits EGF-induced cell migration in Caki-1 cells through inactivation of EGFR and p38 MAPK signaling pathways

Klotho is a single-pass transmembrane protein with documented anti-cancer properties. Recent reports have implicated Klotho as an inhibitor of transforming growth factor β1 induced cell migration in renal fibrosis. Overexpression of epidermal growth factor receptor (EGFR) is known to promote tumor i...

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Detalles Bibliográficos
Autores principales: Dehghani, Mehdi, Brobey, Reynolds K., Wang, Yue, Souza, Glauco, Amato, Robert J., Rosenblatt, Kevin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003560/
https://www.ncbi.nlm.nih.gov/pubmed/29928482
http://dx.doi.org/10.18632/oncotarget.25481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003560/
https://www.ncbi.nlm.nih.gov/pubmed/29928482
http://dx.doi.org/10.18632/oncotarget.25481

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