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Cryptotanshinone hinders renal fibrosis and epithelial transdifferentiation in obstructive nephropathy by inhibiting TGF-β1/Smad3/integrin β1 signal

Recent studies have reported that CTS can alleviate cardiac fibrosis. However, the effects of CTS on kidney fibrosis and EMT are still unknown. This study explored whether CTS could attenuate tubulointerstitial fibrosis as well as EMT, and investigated the potential underlying mechanisms. In this st...

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Detalles Bibliográficos
Autores principales: Wang, Wei, Zhou, Pang-Hu, Hu, Wei, Xu, Chang-Geng, Zhou, Xiang-Jun, Liang, Chao-Zhao, Zhang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003568/
https://www.ncbi.nlm.nih.gov/pubmed/29928474
http://dx.doi.org/10.18632/oncotarget.23803