Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells

Human carbonic anhydrase (CA) IX has emerged as a promising anticancer target and a diagnostic biomarker for solid hypoxic tumors. Novel fluorinated CA IX inhibitors exhibited up to 50 pM affinity towards the recombinant human CA IX, selectivity over other CAs, and direct binding to Zn(II) in the ac...

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Detalles Bibliográficos
Autores principales: Kazokaitė, Justina, Niemans, Raymon, Dudutienė, Virginija, Becker, Holger M., Leitāns, Jānis, Zubrienė, Asta, Baranauskienė, Lina, Gondi, Gabor, Zeidler, Reinhard, Matulienė, Jurgita, Tārs, Kaspars, Yaromina, Ala, Lambin, Philippe, Dubois, Ludwig J., Matulis, Daumantas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003569/
https://www.ncbi.nlm.nih.gov/pubmed/29928486
http://dx.doi.org/10.18632/oncotarget.25508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003569/
https://www.ncbi.nlm.nih.gov/pubmed/29928486
http://dx.doi.org/10.18632/oncotarget.25508

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