Cargando…

Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells

Human carbonic anhydrase (CA) IX has emerged as a promising anticancer target and a diagnostic biomarker for solid hypoxic tumors. Novel fluorinated CA IX inhibitors exhibited up to 50 pM affinity towards the recombinant human CA IX, selectivity over other CAs, and direct binding to Zn(II) in the ac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kazokaitė, Justina, Niemans, Raymon, Dudutienė, Virginija, Becker, Holger M., Leitāns, Jānis, Zubrienė, Asta, Baranauskienė, Lina, Gondi, Gabor, Zeidler, Reinhard, Matulienė, Jurgita, Tārs, Kaspars, Yaromina, Ala, Lambin, Philippe, Dubois, Ludwig J., Matulis, Daumantas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003569/ https://www.ncbi.nlm.nih.gov/pubmed/29928486 http://dx.doi.org/10.18632/oncotarget.25508

Ejemplares similares

Picomolar fluorescent probes for compound affinity determination to carbonic anhydrase IX expressed in live cancer cells
por: Matulienė, Jurgita, et al.
Publicado: (2022)

Measurement of Nanomolar Dissociation Constants by Titration Calorimetry and Thermal Shift Assay – Radicicol Binding to Hsp90 and Ethoxzolamide Binding to CAII
por: Zubrienė, Asta, et al.
Publicado: (2009)

Titration Calorimetry Standards and the Precision of Isothermal Titration Calorimetry Data
por: Baranauskienė, Lina, et al.
Publicado: (2009)

An update on anticancer drug development and delivery targeting carbonic anhydrase IX
por: Kazokaitė, Justina, et al.
Publicado: (2017)

Methyl 2-Halo-4-Substituted-5-Sulfamoyl-Benzoates as High Affinity and Selective Inhibitors of Carbonic Anhydrase IX
por: Zakšauskas, Audrius, et al.
Publicado: (2021)

Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII
por: Morkūnaitė, Vaida, et al.
Publicado: (2014)

Intrinsic thermodynamics of ethoxzolamide inhibitor binding to human carbonic anhydrase XIII
por: Baranauskienė, Lina, et al.
Publicado: (2012)

Prognostic Significance of Carbonic Anhydrase IX Expression in Cancer Patients: A Meta-Analysis
por: van Kuijk, Simon J. A., et al.
Publicado: (2016)

4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases
por: Rutkauskas, Kęstutis, et al.
Publicado: (2014)

New Monoclonal Antibodies for a Selective Detection of Membrane-Associated and Soluble Forms of Carbonic Anhydrase IX in Human Cell Lines and Biological Samples
por: Stravinskiene, Dovile, et al.
Publicado: (2019)

Engineered Carbonic Anhydrase VI-Mimic Enzyme Switched the Structure and Affinities of Inhibitors
por: Kazokaitė, Justina, et al.
Publicado: (2019)

Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding
por: Smirnov, Alexey, et al.
Publicado: (2018)

Thiazide and other Cl-benzenesulfonamide-bearing clinical drug affinities for human carbonic anhydrases
por: Baranauskiene, Lina, et al.
Publicado: (2021)

Switching the Inhibitor‐Enzyme Recognition Profile via Chimeric Carbonic Anhydrase XII
por: Smirnovienė, Joana, et al.
Publicado: (2021)

3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors
por: Pustenko, Aleksandrs, et al.
Publicado: (2017)

Thermodynamics of Aryl-Dihydroxyphenyl-Thiadiazole Binding to Human Hsp90
por: Kazlauskas, Egidijus, et al.
Publicado: (2012)

Correction: Thermodynamics of Aryl-Dihydroxyphenyl-Thiadiazole Binding to Human Hsp90
por: Kazlauskas, Egidijus, et al.
Publicado: (2012)

Structural details of the enzymatic catalysis of carbonic anhydrase II via a mutation of valine to isoleucine
por: Matulis, Daumantas
Publicado: (2020)

Development and Characterization of New Monoclonal Antibodies against Human Recombinant CA XII
por: Dekaminaviciute, Dovile, et al.
Publicado: (2014)

Screening, Synthesis and Biochemical Characterization of SARS-CoV-2 Protease Inhibitors
por: Bagdonas, Martynas, et al.
Publicado: (2023)

Extending the Inhibition Profiles of Coumarin-Based Compounds Against Human Carbonic Anhydrases: Synthesis, Biological, and In Silico Evaluation
por: Kartsev, Victor, et al.
Publicado: (2019)

Intrinsic Thermodynamics and Structure Correlation of Benzenesulfonamides with a Pyrimidine Moiety Binding to Carbonic Anhydrases I, II, VII, XII, and XIII
por: Kišonaitė, Miglė, et al.
Publicado: (2014)

Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases
por: Balandis, Benas, et al.
Publicado: (2022)

Synthesis and HDAC inhibitory activity of pyrimidine-based hydroxamic acids
por: Jakubkiene, Virginija, et al.
Publicado: (2022)

Aryl-4,5-dihydro-1H-pyrazole-1-carboxamide Derivatives Bearing a Sulfonamide Moiety Show Single-digit Nanomolar-to-Subnanomolar Inhibition Constants against the Tumor-associated Human Carbonic Anhydrases IX and XII
por: Hargunani, Priya, et al.
Publicado: (2020)

Inhibition of Carbonic Anhydrase IX Suppresses Breast Cancer Cell Motility at the Single-Cell Level
por: Janoniene, Agne, et al.
Publicado: (2021)

N-Acylbenzenesulfonamide Dihydro-1,3,4-oxadiazole Hybrids: Seeking Selectivity toward Carbonic Anhydrase Isoforms
por: Bianco, Giulia, et al.
Publicado: (2017)

PLBD: protein–ligand binding database of thermodynamic and kinetic intrinsic parameters
por: Lingė, Darius, et al.
Publicado: (2023)

Evofosfamide sensitizes esophageal carcinomas to radiation without increasing normal tissue toxicity
por: Spiegelberg, Linda, et al.
Publicado: (2019)

Factors, associated with elevated concentration of soluble carbonic anhydrase IX in plasma of women with cervical dysplasia
por: Grincevičienė, Švitrigailė, et al.
Publicado: (2022)

Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials
por: Spiegelberg, Linda, et al.
Publicado: (2019)

Coral Carbonic Anhydrases: Regulation by Ocean Acidification
por: Zoccola, Didier, et al.
Publicado: (2016)

ssRNA Phages: Life Cycle, Structure and Applications
por: Tars, Kaspars
Publicado: (2020)

The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy
por: van Kuijk, Simon J. A., et al.
Publicado: (2016)

Selective DNA Gyrase Inhibitors: Multi-Target in Silico Profiling with 3D-Pharmacophores
por: Tomašič, Tihomir, et al.
Publicado: (2021)

Diversity of pili-specific bacteriophages: genome sequence of IncM plasmid-dependent RNA phage M
por: Rumnieks, Janis, et al.
Publicado: (2012)

Discovery and Validation of SIRT2 Inhibitors Based on Tenovin-6: Use of a (1)H-NMR Method to Assess Deacetylase Activity
por: Pirrie, Lisa, et al.
Publicado: (2012)

POT1 stability and binding measured by fluorescence thermal shift assays
por: DeLeeuw, Lynn W., et al.
Publicado: (2021)

Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures
por: Daunys, Simonas, et al.
Publicado: (2019)

Special Issue “Advances in Monitoring Metabolic Activities of Microorganisms by Calorimetry”
por: Matulis, Daumantas, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jnb3qvsa1dbqj3gad7a1d7lu57