Cargando…
FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1‐defective cells
To exploit vulnerabilities of tumors, it is urgent to identify associated defects in genome maintenance. One unsolved problem is the mechanism of regulation of DNA double‐strand break repair by REV7 in complex with 53BP1 and RIF1, and its influence on repair pathway choice between homologous recombi...
Autores principales: | Tomida, Junya, Takata, Kei‐ichi, Bhetawal, Sarita, Person, Maria D, Chao, Hsueh‐Ping, Tang, Dean G, Wood, Richard D |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003645/ https://www.ncbi.nlm.nih.gov/pubmed/29789392 http://dx.doi.org/10.15252/embj.201899543 |
Ejemplares similares
-
REV7 is essential for DNA damage tolerance via two REV3L binding sites in mammalian DNA polymerase ζ
por: Tomida, Junya, et al.
Publicado: (2015) -
The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability
por: Lange, Sabine S., et al.
Publicado: (2016) -
Human DNA helicase HELQ participates in DNA interstrand crosslink tolerance with ATR and RAD51 paralogs
por: Takata, Kei-ichi, et al.
Publicado: (2013) -
SHLD2/FAM35A co‐operates with REV7 to coordinate DNA double‐strand break repair pathway choice
por: Findlay, Steven, et al.
Publicado: (2018) -
Conserved Overlapping Gene Arrangement, Restricted Expression, and Biochemical Activities of DNA Polymerase ν (POLN)
por: Takata, Kei-ichi, et al.
Publicado: (2015)