Late sodium current inhibitors to treat exercise‐induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium

BACKGROUND AND PURPOSE: In 30–40% of hypertrophic cardiomyopathy (HCM) patients, symptomatic left ventricular (LV) outflow gradients develop only during exercise due to catecholamine‐induced LV hypercontractility (inducible obstruction). Negative inotropic pharmacological options are limited to β‐bl...

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Detalles Bibliográficos
Autores principales: Ferrantini, Cecilia, Pioner, Josè Manuel, Mazzoni, Luca, Gentile, Francesca, Tosi, Benedetta, Rossi, Alessandra, Belardinelli, Luiz, Tesi, Chiara, Palandri, Chiara, Matucci, Rosanna, Cerbai, Elisabetta, Olivotto, Iacopo, Poggesi, Corrado, Mugelli, Alessandro, Coppini, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003658/
https://www.ncbi.nlm.nih.gov/pubmed/29579779
http://dx.doi.org/10.1111/bph.14223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003658/
https://www.ncbi.nlm.nih.gov/pubmed/29579779
http://dx.doi.org/10.1111/bph.14223

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