Cargando…

Late sodium current inhibitors to treat exercise‐induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium

BACKGROUND AND PURPOSE: In 30–40% of hypertrophic cardiomyopathy (HCM) patients, symptomatic left ventricular (LV) outflow gradients develop only during exercise due to catecholamine‐induced LV hypercontractility (inducible obstruction). Negative inotropic pharmacological options are limited to β‐bl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferrantini, Cecilia, Pioner, Josè Manuel, Mazzoni, Luca, Gentile, Francesca, Tosi, Benedetta, Rossi, Alessandra, Belardinelli, Luiz, Tesi, Chiara, Palandri, Chiara, Matucci, Rosanna, Cerbai, Elisabetta, Olivotto, Iacopo, Poggesi, Corrado, Mugelli, Alessandro, Coppini, Raffaele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003658/ https://www.ncbi.nlm.nih.gov/pubmed/29579779 http://dx.doi.org/10.1111/bph.14223

Ejemplares similares

Genotype-Driven Pathogenesis of Atrial Fibrillation in Hypertrophic Cardiomyopathy: The Case of Different TNNT2 Mutations
por: Pioner, Josè Manuel, et al.
Publicado: (2022)

Altered Ca(2+) and Na(+) Homeostasis in Human Hypertrophic Cardiomyopathy: Implications for Arrhythmogenesis
por: Coppini, Raffaele, et al.
Publicado: (2018)

Pathogenesis of Hypertrophic Cardiomyopathy is Mutation Rather Than Disease Specific: A Comparison of the Cardiac Troponin T E163R and R92Q Mouse Models
por: Ferrantini, Cecilia, et al.
Publicado: (2017)

Regulation of intracellular Na(+) in health and disease: pathophysiological mechanisms and implications for treatment
por: Coppini, Raffaele, et al.
Publicado: (2013)

T-tubule remodeling in human hypertrophic cardiomyopathy
por: Vitale, Giulia, et al.
Publicado: (2020)

Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy: A Translational Study
por: Coppini, Raffaele, et al.
Publicado: (2019)

R4496C RyR2 mutation impairs atrial and ventricular contractility
por: Ferrantini, Cecilia, et al.
Publicado: (2016)

Clinical Phenotype and Outcome of Hypertrophic Cardiomyopathy Associated With Thin-Filament Gene Mutations
por: Coppini, Raffaele, et al.
Publicado: (2014)

Paradoxical prolongation of QT interval during exercise in patients with hypertrophic cardiomyopathy: cellular mechanisms and implications for diastolic function
por: Coppini, Raffaele, et al.
Publicado: (2022)

Mavacamten has a differential impact on force generation in myofibrils from rabbit psoas and human cardiac muscle
por: Scellini, Beatrice, et al.
Publicado: (2021)

Advances in Stem Cell Modeling of Dystrophin-Associated Disease: Implications for the Wider World of Dilated Cardiomyopathy
por: Pioner, Josè Manuel, et al.
Publicado: (2020)

Pharmacological Management of Hypertrophic Cardiomyopathy: From Bench to Bedside
por: Palandri, Chiara, et al.
Publicado: (2022)

Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy
por: Crocini, C., et al.
Publicado: (2016)

Slower Calcium Handling Balances Faster Cross-Bridge Cycling in Human MYBPC3 HCM
por: Pioner, Josè Manuel, et al.
Publicado: (2023)

Impact of detubulation on force and kinetics of cardiac muscle contraction
por: Ferrantini, Cecilia, et al.
Publicado: (2014)

The relation between sarcomere energetics and the rate of isometric tension relaxation in healthy and diseased cardiac muscle
por: Vitale, Giulia, et al.
Publicado: (2019)

Hypertrophic cardiomyopathy: The need for randomized trials
por: Olivotto, Iacopo, et al.
Publicado: (2013)

A Novel Method of Isolating Myofibrils From Primary Cardiomyocyte Culture Suitable for Myofibril Mechanical Study
por: Woulfe, Kathleen C., et al.
Publicado: (2019)

Optical Investigation of Action Potential and Calcium Handling Maturation of hiPSC-Cardiomyocytes on Biomimetic Substrates
por: Pioner, Josè Manuel, et al.
Publicado: (2019)

Calcium handling maturation and adaptation to increased substrate stiffness in human iPSC-derived cardiomyocytes: The impact of full-length dystrophin deficiency
por: Pioner, Josè Manuel, et al.
Publicado: (2022)

Corrigendum: Calcium handling maturation and adaptation to increased substrate stiffness in human iPSC-derived cardiomyocytes: the impact of full-length dystrophin deficiency
por: Pioner, Josè Manuel, et al.
Publicado: (2023)

Defining the diagnostic effectiveness of genes for inclusion in panels: the experience of two decades of genetic testing for hypertrophic cardiomyopathy at a single center
por: Mazzarotto, Francesco, et al.
Publicado: (2018)

T-Tubular Electrical Defects Contribute to Blunted β-Adrenergic Response in Heart Failure
por: Crocini, Claudia, et al.
Publicado: (2016)

Ion Channel Impairment and Myofilament Ca(2+) Sensitization: Two Parallel Mechanisms Underlying Arrhythmogenesis in Hypertrophic Cardiomyopathy
por: Santini, Lorenzo, et al.
Publicado: (2021)

Optogenetics design of mechanistically-based stimulation patterns for cardiac defibrillation
por: Crocini, Claudia, et al.
Publicado: (2016)

Contemporary Insights Into the Genetics of Hypertrophic Cardiomyopathy: Toward a New Era in Clinical Testing?
por: Mazzarotto, Francesco, et al.
Publicado: (2020)

Pharmacological Inhibition of Serine Proteases to Reduce Cardiac Inflammation and Fibrosis in Atrial Fibrillation
por: Coppini, Raffaele, et al.
Publicado: (2019)

Real-World Use and Predictors of Response to Disopyramide in Patients with Obstructive Hypertrophic Cardiomyopathy
por: Maurizi, Niccolò, et al.
Publicado: (2023)

Alpha and beta myosin isoforms and human atrial and ventricular contraction
por: Walklate, Jonathan, et al.
Publicado: (2021)

RNA‐seq profiling reveals different pathways between remodeled vessels and myocardium in hypertrophic cardiomyopathy
por: Pisano, Annalinda, et al.
Publicado: (2022)

Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy
por: Passini, Elisa, et al.
Publicado: (2016)

Stage-specific therapy for hypertrophic cardiomyopathy
por: Argirò, Alessia, et al.
Publicado: (2023)

Microvascular Dysfunction in Hypertrophic Cardiomyopathy
por: Pelliccia, Francesco, et al.
Publicado: (2022)

Trabeculated Myocardium in Hypertrophic Cardiomyopathy: Clinical Consequences
por: Casanova, José David, et al.
Publicado: (2020)

Emerging Medical Treatment for Hypertrophic Cardiomyopathy
por: Argirò, Alessia, et al.
Publicado: (2021)

Cardiac safety assessment of a novel recombinant bispecific antibody targeting the ether-à-go-go related gene 1 (hERG1)-β1 integrin macromolecular complex
por: Santini, Lorenzo, et al.
Publicado: (2023)

Diagnostic and prognostic electrocardiographic features in patients with hypertrophic cardiomyopathy
por: Bernardini, Andrea, et al.
Publicado: (2023)

An unexpected cause of hypertrophic myocardium
por: Mathew, George Lathra, et al.
Publicado: (2015)

Genetic profile of hypertrophic cardiomyopathy in Tunisia: Is it different?
por: Jaafar, Nawel, et al.
Publicado: (2015)

Cardiac Myosin Inhibitors as a Novel Treatment Option for Obstructive Hypertrophic Cardiomyopathy: Addressing the Core of the Matter
por: Masri, Ahmad, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lovq6gpuvre4jjedugdvrjl8b2