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Inhibitory effect of SLIT2 on granulosa cell proliferation mediated by the CDC42-PAKs-ERK1/2 MAPK pathway in the prehierarchical follicles of the chicken ovary

The SLIT2 ligand and ROBO receptors of the SLIT/ROBO pathway are expressed in hen ovarian follicles and have been shown to play critical roles in ovary development, cell proliferation and apoptosis in mammals. However, the exact roles of SLIT2 and the molecular mechanisms of chicken follicle develop...

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Detalles Bibliográficos
Autores principales: Xu, Rifu, Qin, Ning, Xu, Xiaoxing, Sun, Xue, Chen, Xiaoxia, Zhao, Jinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003946/
https://www.ncbi.nlm.nih.gov/pubmed/29907785
http://dx.doi.org/10.1038/s41598-018-27601-z