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MicroRNA-focused CRISPR-Cas9 library screen reveals fitness-associated miRNAs
MicroRNAs (miRNAs) are post-transcriptional gene regulators that play important roles in the control of cell fitness, differentiation, and development. The CRISPR-Cas9 gene-editing system is composed of the Cas9 nuclease in complex with a single guide RNA (sgRNA) and directs DNA cleavage at a predet...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004052/ https://www.ncbi.nlm.nih.gov/pubmed/29720387 http://dx.doi.org/10.1261/rna.066282.118 |