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Structure–function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t(6)A tRNA modification
N(6)-threonyl-carbamoyl adenosine (t(6)A) is a universal tRNA modification found at position 37, next to the anticodon, in almost all tRNAs decoding ANN codons (where N = A, U, G, or C). t(6)A stabilizes the codon–anticodon interaction and hence promotes translation fidelity. The first step of the b...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004061/ https://www.ncbi.nlm.nih.gov/pubmed/29650678 http://dx.doi.org/10.1261/rna.066092.118 |